Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization

Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization

Significant advancements have been made in the catalytic asymmetric dearomatization of indoles for constructing valuable chiral polycyclic N-heterocycles. However, the asymmetric dearomative cyclopropanation of indoles continues to pose a formidable challenge. Furthermore, the diverse transformation...

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Bibliographic Details
Main Author: Wen-Feng Luo (8200965) (author)
Other Authors: Li-Gao Liu (20955812) (author), Yan-Xin Zheng (20944488) (author), Miao Sun (59967) (author), Xin Lu (24821) (author), Bo Zhou (15092) (author), Long-Wu Ye (1507885) (author), Long Li (6555) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Genetics
Molecular Biology
Immunology
Plant Biology
Chemical Sciences not elsewhere classified
potential reaction pathways
generally outstanding diastereo
catalytic asymmetric dearomatization
broad substrate scope
asymmetric dearomative cyclopropanation
indoles utilizing alkynes
chiral control within
control experiments
three types
theoretical calculations
robustly supported
promoted ring
indoles continues
high stereoselectivity
fused indolines
formidable challenge
excellent yields
excellent efficiency
enantioselective synthesis
economical synthesis
diverse transformations
chiral 1
carbene precursors
brønsted acid
b </
also constitutes
>]­ indoles
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