Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization

Significant advancements have been made in the catalytic asymmetric dearomatization of indoles for constructing valuable chiral polycyclic N-heterocycles. However, the asymmetric dearomative cyclopropanation of indoles continues to pose a formidable challenge. Furthermore, the diverse transformation...

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Bibliographic Details
Main Author:	Wen-Feng Luo (8200965) (author)
Other Authors:	Li-Gao Liu (20955812) (author), Yan-Xin Zheng (20944488) (author), Miao Sun (59967) (author), Xin Lu (24821) (author), Bo Zhou (15092) (author), Long-Wu Ye (1507885) (author), Long Li (6555) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Genetics Molecular Biology Immunology Plant Biology Chemical Sciences not elsewhere classified potential reaction pathways generally outstanding diastereo catalytic asymmetric dearomatization broad substrate scope asymmetric dearomative cyclopropanation indoles utilizing alkynes chiral control within control experiments three types theoretical calculations robustly supported promoted ring indoles continues high stereoselectivity fused indolines formidable challenge excellent yields excellent efficiency enantioselective synthesis economical synthesis diverse transformations chiral 1 carbene precursors brønsted acid b </ also constitutes >] indoles
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Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N‑Heterocycles via Copper-Catalyzed Dearomative Cyclization

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