RIα<sup>Y122A</sup> disrupts cAMP-stimulated RIα LLPS.

RIα<sup>Y122A</sup> disrupts cAMP-stimulated RIα LLPS.

<p><b>(A)</b> Representative maximum intensity projections from confocal Z-stacks showing GFP expression <b>(left)</b> and quantification of puncta per cell <b>(right)</b> from HEK293T cells co-expressing Cα-mCherry plus GFP2-tagged RIα<sup>WT</sup&...

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Bibliographic Details
Main Author:	Ha Neul Lee (7360352) (author)
Other Authors:	Julia C. Hardy (21781692) (author), Emily H. Pool (14883318) (author), Jin-Fan Zhang (21781695) (author), Su Hyun Kim (828853) (author), William F. Buhl (21781698) (author), Jessica G.H. Bruystens (21781701) (author), Sohum Mehta (2000764) (author), Susan S. Taylor (44167) (author), Jin Zhang (53297) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Developmental Biology Cancer Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified ubiquitous second messenger selective molecular tool reveal key roles prevent uncontrolled proliferation min6 β cells mediated gene expression facilitate spatial compartmentalization dependent protein kinase cyclic adenosine monophosphate control insulin secretion based riα knockout exhibits defective camp camp oscillation frequency div >< p 2 +</ sup studying riα llps pka ), riα camp ), riα mutant riα llps riα condensates regulatory subunit regulate creb previously showed pka type phase separation largely unknown induced llps high specificity functional impact data establish combining crispr cellular functions
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