HUWE1 enhances WNT signaling through mechanisms mediated by APC.

<p>The same cell lines were used in A-F. WT HAP1-7TGP cells were treated with 50% WNT3A CM for 24 hr where indicated. (A) Immunoblot analysis of soluble proteins in MFS of the indicated clonal cell lines. We note that CSNK1A1<sup>KO-2</sup> cells contain a loss-of-function mutation...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Joseph K. McKenna (21433661) (author)
مؤلفون آخرون:	Yalan Wu (9626045) (author), Praveen Sonkusre (18172909) (author), Caleb K. Sinclear (21433664) (author), Raj Chari (23305) (author), Andres M. Lebensohn (6273824) (author)
منشور في:	2025
الموضوعات:	Biochemistry Cell Biology Molecular Biology Neuroscience Developmental Biology Cancer overexpression analyses revealed second signaling step scaffold proteins apc destruction complex composed antagonizes destruction complex reduced ctnnb1 alone ctnnb1 variant insensitive huwe1 also requires huwe1 enhances wnt reducing ctnnb1 abundance change ctnnb1 abundance ubiquitin ligase activity transcriptional coactivator β gsk3b still phosphorylated div >< p huwe1 loss resulted huwe1 loss required hyperactive wnt signaling antagonizing destruction complex wnt signaling caused dependent ctnnb1 phosphorylation mediated ctnnb1 degradation destruction complex ctnnb1 abundance also apc huwe1 loss wnt signaling ctnnb1 signaling ctnnb1 caused huwe1 would targeting ctnnb1 ctnnb1 </ ctnnb1 ). two mechanisms test whether robust activation proteasomal degradation mediated phosphorylation mechanism underlying genetic interaction enabling sensitive efficient way catenin signaling
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

HUWE1 enhances WNT signaling through mechanisms mediated by APC.

مواد مشابهة