Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2<sup>+</sup> Breast Cancer

Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2<sup>+</sup> Breast Cancer

Ionizable lipid nanoparticles (LNPs) have enabled significant advances in oligonucleotide (ON) therapeutics, resulting in the approval of the short interfering RNA (siRNA)-based formulation Onpattro. However, achieving cell-specific delivery remains challenging. We have developed palmitate-containin...

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Bibliografiske detaljer
Hovedforfatter: Pedro Medina (454632) (author)
Andre forfattere: Modesto Orozco (10295) (author), Montserrat Terrazas (2195023) (author)
Udgivet: 2025
Fag:
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Pharmacology
Biotechnology
Cancer
Computational Biology
Space Science
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
sup >+</ sup
short interfering rna
palmitic acid inclusion
novel lnp formulation
enabled significant advances
containing lipid nanoparticles
tumor cells compared
breast cancer cells
demonstrating strong potential
dually decorated palmitate
based targeted therapies
sensitive cells
targeted delivery
potential use
combinatorial therapies
targeting peptide
sirna combination
results support
promoting genes
diverse tumors
developed palmitate
combination treatments
achieving cell
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