LDLR is induced by MK-2206 in a SREBP2-dependent manner.

LDLR is induced by MK-2206 in a SREBP2-dependent manner.

<p>The effect of SREBP2 depletion on MK-2206 (MK) induction of LDLR and autophagy was evaluated transient in HepG2: <b>A)</b> HepG2 cells were targeted with siRNA against control (mock) or SREBP2 for 24 h alone or B) prior to MK-2206 (5 µM) treatment for 14-16 <b>h.</b>...

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Bibliographic Details
Main Author: Hilde Sundvold (2581642) (author)
Other Authors: Thea Bismo Strøm (17537525) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Molecular Biology
Physiology
Pharmacology
Virology
Chemical Sciences not elsewhere classified
key risk factor
hap1 cell lines
genetically via short
ensure complete abrogation
atherosclerotic cardiovascular disease
modulating cholesterol efflux
akt inhibitors mk
mediated ldlr upregulation
induced ldlr expression
enhancing ldlr expression
autophagy regulates mk
xlink "> mk
atg7 hap1 cells
autophagy marker lc3b
sirna targeting atg5
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targeting autophagy
primarily mediated
cholesterol metabolism
type cells
deficient cells
autophagy induction
autophagy attenuate
ulk1 </
substantial reduction
study examines
stable knockout
srebp2 silencing
sqstm1 </
show evidence
related genes
possible effect
p62 </
mrna levels
member 1
lowering therapies
interfering rna
inducing effects
genetic impairment
established target
density lipoprotein
cvd prevention
cvd ).
atg7 </
atg5 </
approximately 50
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