NMF provides interpretable decomposition of single-molecule chromatin conformation datasets.

<p>a. Matrices representing the median all-by-all Euclidean difference (nm) between genomic loci in single molecules at a 30 kb locus in <i>Drosophila melanogaster</i> actively transcribing (left) and not transcribing (middle) the Abd-A gene from Mateo et al.[<a href="http:...

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Bibliographic Details
Main Author:	Laura M. Gunsalus (9234497) (author)
Other Authors:	Michael J. Keiser (260659) (author), Katherine S. Pollard (8685789) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Biotechnology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified salient primary components occurring uniformly across negative matrix factorization key functional phenotypes including active transcription identifying causal relationships fostering new insights identify trends accounting individual dna molecules individual chromatin fibers genome organization may bulk trends exist molecule chromatin organization individual molecules chromatin organization bulk trends molecule data genome structure chromatin structure xlink "> small fraction simultaneously describing robust tool promoter distance maximum variance genomic compartment critical changes complex interplay cellular heterogeneity cell level
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NMF provides interpretable decomposition of single-molecule chromatin conformation datasets.

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