IL-10 protects μMT-/- mice chronically infected with Plasmodium chabaudi by preventing excessive inflammatory responses.

Chronically infected μMT-/- mice were treated via intraperitoneal injection with an anti-IL-10 receptor monoclonal antibody (mAb) or an isotype mAb control at days 84 (500 µg of mAb/mouse), 88 (500 µg of mAb/mouse), 91 (250 µg of mAb/mouse), and 94 (250 µg of mAb/mous...

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Main Author:	Leandro de Souza Silva (355883) (author)
Other Authors:	Brian G. Monks (22279154) (author), Catherine S. Forconi (8737737) (author), Juliet N. Crabtree (4259071) (author), Nelsy De Paula Tamburro (22279157) (author), Evelyn A. Kurt-Jones (22279160) (author), Ricardo T. Gazzinelli (164680) (author), Katherine A. Fitzgerald (7633592) (author), Douglas T. Golenbock (243118) (author)
Published:	2025
Subjects:	Medicine Microbiology Cell Biology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified sup >-/-</ sup rapid weight loss excessive inflammatory responses depleted infected µmt chronically infected µmt >- infected µmt cells limits immune 10 limits immune sustained elevated levels slightly elevated levels chronically infected mice subclinical parasitemia constitutes div >< p infected µmt elevated levels inflammatory response microscopic levels high levels 10 levels elevated il similar outcome robust pro results showed predominant proportion plasmodium </ pc </ outward signs mice exhibit mice ). mediated pathology mechanistically linked ifnγ ), hyperendemic regions extensively studied day 6 chronic subclinical cell depletion albeit transient acute symptomatic 99 days 10r resulted 10 signaling
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IL-10 protects μMT<sup>-/-</sup> mice chronically infected with <i>Plasmodium chabaudi</i> by preventing excessive inflammatory responses.

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