Reaction-Guided Metabolomics Accelerates High-Throughput Annotation of Xenobiotic Metabolites for Human Exposome

The human exposome features a highly expansive chemical space and substantial individual variability. Although screenings of xenobiotic compounds have revealed exposure landscapes of specific compounds, significant bottlenecks remain in profiling their biotransformed products for comprehensive expos...

詳細記述

保存先:

書誌詳細
第一著者:	Haoduo Zhao (9672279) (author)
その他の著者:	Yun-Chung Hsiao (9193862) (author), Chih-Wei Liu (2173081) (author), Jiahao Feng (9464618) (author), Xueying Wang (281924) (author), Jingya Peng (18979159) (author), Taylor Teitelbaum (18979162) (author), Kun Lu (404977) (author)
出版事項:	2025
主題:	Biochemistry Genetics Pharmacology Biotechnology Ecology Sociology Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified substantial individual variability spectrum similarity network significant bottlenecks remain significant advancement toward revealed exposure landscapes layered architecture comprising following multichannel validation extensive exposure spectrum course logistic modeling widespread human exposure including standard verification demonstrated using pesticides 886 biotransformed derivatives 2 </ sup 1 </ sup retention time prediction new metabolite annotation human exposome features human exposome including limitations human cohort biotransformed products 021 pesticides comprehensive exposome xenobiotic metabolites xenobiotic compounds wide analysis untargeted metabolomics unprecedented throughput throughput annotation specific compounds scalable workflow representative example murine studies low throughput known metabolites identified metabolites first time facilitate high documented toxicity candidature space based pseudo although screenings
タグ:	タグ追加タグなし, このレコードへの初めてのタグを付けませんか!

Reaction-Guided Metabolomics Accelerates High-Throughput Annotation of Xenobiotic Metabolites for Human Exposome

類似資料