Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates

The first asymmetric total synthesis of the bisbenzylisoquinoline alkaloids berbamine (<b>1a</b>) and oxyacanthine (<b>1b</b>) has been accomplished by employing Noyori asymmetric hydrogenation for chirality installation and leveraging copper-mediated Ullmann coupling for mac...

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主要作者:	Li Xiang (586649) (author)
其他作者:	Jishan Qin (20535872) (author), Temur Kushatov (22687969) (author), Firdavsi Tursunov (22687972) (author), Ozod Farmonov (22687975) (author), Xiangrui Jiang (1601968) (author), Feipu Yang (2937366) (author), Jingshan Shen (1601962) (author), Khurshed Bozorov (5517845) (author), Haji Akber Aisa (7312430) (author)
出版:	2025
主题:	Biochemistry Microbiology Physiology Biotechnology Ecology Immunology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified synthesis unequivocally confirmed stimulated raw 264 promising lead candidate mediated ullmann coupling asymmetric total synthesis inflammatory activities revealed 15a </ b inflammatory activity coupled displayed potent anti inflammatory cytokines il oxyacanthine (< b inflammatory activity inflammatory agents sample misidentification related intermediates previous work novel anti minimal cytotoxicity macrocycle formation leveraging copper chirality installation 7 macrophages
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