Genetic modifications of Ad11 for tumor-selectivity and evaluation of tumor-selective replication.

Genetic modifications of Ad11 for tumor-selectivity and evaluation of tumor-selective replication.

<p><b>(A)</b> Genome sequence alignment of wild-type Ad5, wild-type Ad11, and modified Ad11 in the promoter region of the E1A gene. The endogenous promoter region of wild-type Ad11 was replaced with E2F1 promoter in the modified Ad11, resulting in its tumor-selective replication. &...

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Bibliographic Details
Main Author: Masahisa Hemmi (21601907) (author)
Other Authors: Midori Yamashita (21601910) (author), Yoshiko Shimizu (171960) (author), Shinsuke Nakao (52048) (author)
Published: 2025
Subjects:
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Ecology
Immunology
Cancer
Mental Health
Hematology
Infectious Diseases
Virology
Chemical Sciences not elsewhere classified
shown clinical benefit
promising therapeutic approach
minimum binding affinity
ad11 antibody clones
killing cancer cells
cancer cells
inhibit binding
cancer types
cancer treatment
vec ),
unique modality
talimogene laherparepvec
several limitations
selectively replicate
prevent use
oncolytic viruses
natural receptor
multifaceted mechanisms
intravenous administration
intratumoral administration
human erythrocytes
ensuring safe
class agent
broader range
advanced melanoma
ad11 fibers
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