Genetic modifications of Ad11 for tumor-selectivity and evaluation of tumor-selective replication.
<p><b>(A)</b> Genome sequence alignment of wild-type Ad5, wild-type Ad11, and modified Ad11 in the promoter region of the E1A gene. The endogenous promoter region of wild-type Ad11 was replaced with E2F1 promoter in the modified Ad11, resulting in its tumor-selective replication. &...
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2025
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