Identification of therapeutic drugs with high drug sensitivity for brain metastasis-associated tumor cells (MBMATCs) and high-brain metastasis (MBM) index patients.

Identification of therapeutic drugs with high drug sensitivity for brain metastasis-associated tumor cells (MBMATCs) and high-brain metastasis (MBM) index patients.

<p>(A-I) Differential drug-response analysis (boxplots) and Spearman’s correlation analysis (right panel) for Mirin_1048, PR-4708671_1129 and XAV939_1268.</p> <p>(TIF)</p>

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Detalles Bibliográficos
Autor Principal:	Jingxin Zeng (18773484) (author)
Outros autores:	Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Publicado:	2025
Subjects:	Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </
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