DataSheet_1_A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.docx

DataSheet_1_A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.docx

<p>Saturation suppressor mutagenesis was used to generate thermostable mutants of the SARS-CoV-2 spike receptor-binding domain (RBD). A triple mutant with an increase in thermal melting temperature of ~7°C with respect to the wild-type B.1 RBD and was expressed in high yield in both mammalian...

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Main Author: Shahbaz Ahmed (9365513) (author)
Other Authors: Mohammad Suhail Khan (11134087) (author), Savitha Gayathri (153633) (author), Randhir Singh (6433571) (author), Sahil Kumar (8344614) (author), Unnatiben Rajeshbhai Patel (11134057) (author), Sameer Kumar Malladi (11815970) (author), Raju S. Rajmani (11134060) (author), Petrus Jansen van Vuren (11134066) (author), Shane Riddell (11026434) (author), Sarah Goldie (9473981) (author), Nidhi Girish (11134081) (author), Poorvi Reddy (11134078) (author), Aditya Upadhyaya (11134084) (author), Suman Pandey (788283) (author), Samreen Siddiqui (10888146) (author), Akansha Tyagi (10888149) (author), Sujeet Jha (10888185) (author), Rajesh Pandey (4378585) (author), Oyahida Khatun (11815973) (author), Rohan Narayan (11815976) (author), Shashank Tripathi (217576) (author), Alexander J. McAuley (11026437) (author), Nagendrakumar Balasubramanian Singanallur (11815979) (author), Seshadri S. Vasan (10308212) (author), Rajesh P. Ringe (3118764) (author), Raghavan Varadarajan (76468) (author)
Published: 2021
Subjects:
Immunology
Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
Autoimmunity
Cellular Immunology
Humoural Immunology and Immunochemistry
Immunogenetics (incl. Genetic Immunology)
Innate Immunity
Transplantation Immunology
Tumour Immunology
Immunology not elsewhere classified
Genetic Immunology
Animal Immunology
Veterinary Immunology
stabilizing mutation
hyperstable mutants
neutralizing antibodies
hamster immunization
vaccination
lyophilization
thermotolerance
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