Inhibition of PGAM5 and apoptosis alleviated the rTsSPc-damaged Caco-2 monolayer barrier integrity.

<p>PGAM5 inhibitor LFHP-1c and an apoptosis inhibitor Z-VAD-FMK were used to impede rTsSPc-induced disruption of Caco-2 monolayer barrier function. To inhibit the PGAM5 and cell apoptosis, Caco-2 monolayers were pretreated with 2 μM LFHP-1c for 9 h or 2 μM LFHP-1c for 9 h + 120 μM Z-VAD-FMK fo...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Qi Qi Lu (17721401) (author)
مؤلفون آخرون:	Xin Zhuo Zhang (15222763) (author), Pei Kun Cong (20598539) (author), Jin Yi Wu (20598536) (author), Tian Ran Gao (22530555) (author), Shao Rong Long (8770949) (author), Ruo Dan Liu (8770934) (author), Zhong Quan Wang (7592999) (author), Jing Cui (28824) (author)
منشور في:	2025
الموضوعات:	Biochemistry Cell Biology Genetics Molecular Biology Physiology Ecology Immunology Developmental Biology Cancer Inorganic Chemistry Science Policy Infectious Diseases Chemical Sciences not elsewhere classified western blot revealed previous studies showed fmk ), trans flow cytometry showed epithelial electrical resistance candidate vaccine target promoting larval invasion promotes larval invasion promoted larval invasion mediate larval invasion interdict larval invasion trichinella spiralis </ thereby induced caco rtsspc triggered caco apoptosis prevented rtsspc 2 cell apoptosis 2 monolayer integrity larval invasion spiralis </ 2 monolayer induced apoptosis 2 apoptosis barrier integrity rtsspc significantly rtsspc bound rtsspc binding 2 cells inducing apoptosis apoptosis pathway xlink "> tight junctions specific sirna serine protease secretory proteins related proteins pi staining obviously increased key molecules intestinal permeability immunofluorescence test gut mucosa findings indicated evidently decreased crucial procedure caspase 9 caspase 8 caspase 3 barrier function annexin v also decreased
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Inhibition of PGAM5 and apoptosis alleviated the rTsSPc-damaged Caco-2 monolayer barrier integrity.

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