Data Sheet 1_Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity.pdf

Data Sheet 1_Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity.pdf

Introduction<p>Increased CYP3A-mediated drug clearance during pregnancy can lead to subtherapeutic dosing of CYP3A substrates. Pregnancy-related hormones (PRHs) increase CYP3A4 expression and activity in cultured human hepatocytes. However, the factors in maternal circulation that regulate pre...

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Bibliographic Details
Main Author: Muluneh M. Fashe (13836118) (author)
Other Authors: Jonghwa Lee (3918998) (author), Joseph T. Grieco (22687382) (author), John K. Fallon (1329057) (author), Ian R. Mulrenin (16506765) (author), Megan N. Gower (22687385) (author), Klarissa D. Jackson (4744389) (author), Kim A. Boggess (2882261) (author), Craig R. Lee (10650905) (author)
Published: 2025
Subjects:
Pharmacology
pregnancy
CYP3A4
hepatic metabolism
estrone
estradiol
4β-hydroxycholesterol
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