Adoptive transfer of ARPV/ZIKV-primed T-cells to naïve mice pre-challenge resulted in increased median survival times.

<p>Single-cell suspensions of CD4+ or CD8+ T-cells were prepared from the spleens of C57BL/6J mice 30 days after vaccination, then injected into naïve IFN-αβR<sup>-/-</sup> mice 24 hours before challenge. Mice were then monitored for survival (a, b) and weight change (c, d). (c, d)...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Danielle L. Porier (11241343) (author)
مؤلفون آخرون:	Awadalkareem Adam (8980547) (author), Lin Kang (46742) (author), Pawel Michalak (33549) (author), Juselyn Tupik (19832380) (author), Matthew A. Santos (19832383) (author), Manette Tanelus (11241337) (author), Krisangel López (808377) (author), Dawn I. Auguste (11241346) (author), Christy Lee (15159810) (author), Irving C. Allen (8055023) (author), Tian Wang (115287) (author), Albert J. Auguste (10195925) (author)
منشور في:	2024
الموضوعات:	Molecular Biology Immunology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified sup >-/-</ sup sup >+</ sup shown exceptional safety previously created pre day median increase protective immune responses protective immunity induced mice passively immunized licensed vaccines exist immune responses induced neutralizing antibody responses survival time compared div >< p clinical zika virus cells may play based flavivirus vaccines mediated responses induced zikv challenge showed lethal zikv challenge flavivirus vaccine development mediated responses specific flavivirus neutralizing antibodies vaccine optimization vaccine candidate primarily mediated mice resulted mice depleted cell responses induced protection induced cell zikv ). vaccinated ifn strong focus still needed specific flaviviruses results suggest recipient ifn promising tool immunocompromised ifn flaviviruses represent detailed assessment cumulative role comparatively minor called aripo adoptive transfer
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Adoptive transfer of ARPV/ZIKV-primed T-cells to naïve mice pre-challenge resulted in increased median survival times.

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