EGF and VEGF increased Notch activity, which promoted epithelial-to-mesenchymal transition and VM morphogenesis in PDAC cells.

EGF and VEGF increased Notch activity, which promoted epithelial-to-mesenchymal transition and VM morphogenesis in PDAC cells.

<p>The expression of (A) <i>NOTCH1</i> and Notch target genes (B) <i>HEY1</i> and (C) <i>NRARP</i> were determined in PANC-1 cells treated with EGF or VEGF. (D) The expression levels of an epithelial gene <i>CDH1</i> and mesenchymal genes, includ...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Nontawat Benjakul (14295081) (author)
مؤلفون آخرون:	Nattapa Prakobphol (14295084) (author), Chayada Tangshewinsirikul (4678393) (author), Wirada Dulyaphat (14295087) (author), Jisnuson Svasti (2427940) (author), Komgrid Charngkaew (4385962) (author), Thaned Kangsamaksin (4678396) (author)
منشور في:	2022
الموضوعات:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Immunology Developmental Biology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified promotes cell morphogenesis molecular mechanisms underlying generally also hypovascularized notch signaling plays pdac cell lines human pdac tissues div >< p inducing vm formation vm formation notch activity vm capacity vasculogenic mimicry twist1 </ tumor size tumor cells statistical significance solid tumors snai1 </ several types secretase inhibitor positive correlation periodic acid perfusing channels nuclear localization notch1 expression mesenchymal transition like structures important role forming tube desmoplastic areas data showed
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