Comparison of ecDNA and DNase in GCTs patients according to stage (A, B) and number of metastatic sites (C, D).

<p>Comparison of ecDNA and DNase in GCTs patients according to stage (A, B) and number of metastatic sites (C, D).</p>

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Bibliographic Details
Main Author:	Mego Michal (22783828) (author)
Other Authors:	Vlkova Barbora (22783831) (author), Kalavska Katarina (22783834) (author), Pastorek Michal (22783837) (author), Cierna Zuzana (22783840) (author), Sestakova Zuzana (22783843) (author), Chovanec Miroslav (22783846) (author), Udvorkova Natalia (22783849) (author), Kucerova Lucia (22783852) (author), Celec Peter (22783855) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Science Policy Infectious Diseases translational utility remains significantly worse progression neutrophil extracellular trap immune inflammatory index five times higher different subcellular origin 2 cisr xenografts prolonged animal survival human recombinant dnase worse overall survival total extracellular dna worse clinical outcome endogenous dnase levels higher total ecdna 117 gct patients gct patients compared plasma dnase level overall survival clinical outcome total ecdna os compared free survival ecdna levels gct patients therapeutic outcome plasma dnase exogeneous dnase dna species dna damage gct model xlink "> unfavourable response pulmozyme combination prognostic value plasma ecdna lower ecdna low level inverse correlation inferior pfs high level ecdna ), delayed growth data demonstrate data confirm combined treatment 05 ).
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