Schematic diagram of the sarcoplasmic reticulum Ca<sup>2+</sup>-leak experiment.

Schematic diagram of the sarcoplasmic reticulum Ca<sup>2+</sup>-leak experiment.

<p>Ventricular myocytes loaded with Fluo-3 were used to determine SR Ca<sup>2+</sup>-leak, using tetracaine (1mM) in EGTA solution to block Ca<sup>2+</sup>-leak through ryanodine receptors (RyR2).</p>

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Bibliographic Details
Main Author:	Hadeel S. Al Ali (20570578) (author)
Other Authors:	Glenn C. Rodrigo (7666622) (author), David G. Lambert (7639172) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Molecular Biology Physiology Pharmacology Immunology Cancer Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified reducing adverse remodeling peptide urotensin ii camkii signalling pathways alleviating contractile dysfunction adult rat hearts high levels contribute signalling pathways involved signalling molecules involved 99 ± 0 53 ± 0 ventricular myocytes isolated left ventricular hypertrophy div >< p ut receptor activation isolated myocytes receptor ut circulating levels western blotting significant increase sarcoplasmic reticulum results suggest population worldwide pharmacological inhibition marked elevation large section induced hypertrophy heart failure data suggest cardiac hypertrophy antagonist sb657510 1μm ).
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