Characterization of the inhibitory activity of HR2 peptides in pseudovirus infection and cell-cell fusion.

<p>(A) Inhibition of pseudovirus infectivity by the 36-HR2 (black circles), 42-HR2 (green circles) and 36-HR2-HA (pink circles) peptides against D614G pseudovirus infection of 293T cells expressing ACE2/TMPRSS2. (B) Interaction of 42-HR1, HA-HR1 (YPYDVPDYAGPGGSGSG-42-HR1) or HR1-HA (42-HR1-GSG...

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Bibliographic Details
Main Author:	Sabrina Lusvarghi (2329267) (author)
Other Authors:	Russell Vassell (218358) (author), Brittany Williams (15236740) (author), Haseebullah Baha (17364846) (author), Sabari Nath Neerukonda (10284926) (author), Carol D. Weiss (7377635) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Neuroscience Cancer Infectious Diseases Virology Chemical Sciences not elsewhere classified induce conformational changes expose conserved sites heptad repeat 2 trapping fusion intermediates mediate virus fusion inhibit membrane fusion findings elucidate fusion allow s1 shedding s2 transmembrane subunit s2 &# 8217 site </ p transient spike conformations spike s1 subunit 2 spike variants fusion intermediate though hr2 peptide disrupts ace2 binding alone fusion conformations 2 spikes omicron variants investigate fusion fusion conformation peptide captures intermediate conformations hr2 peptide natural s1 unwinding s2 s2 intermediate spikes lacking results indicate involve exposure intermediate relative intermediate conformation hr2 regions helix bundle electron microscopy also present ace2 engagement
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Characterization of the inhibitory activity of HR2 peptides in pseudovirus infection and cell-cell fusion.

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