Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif
Introduction<p>Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed to explore the association between spicy food consumption and the risk of non-alcoholic fatty liver disease (N...
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2025
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| _version_ | 1849927624461123584 |
|---|---|
| author | Na Zhao (112953) |
| author2 | Huimin Liu (284624) Yan Wang (15435) Yun He (40953) Ning Zhang (23771) Yuan Li (67017) |
| author2_role | author author author author author |
| author_facet | Na Zhao (112953) Huimin Liu (284624) Yan Wang (15435) Yun He (40953) Ning Zhang (23771) Yuan Li (67017) |
| author_role | author |
| dc.creator.none.fl_str_mv | Na Zhao (112953) Huimin Liu (284624) Yan Wang (15435) Yun He (40953) Ning Zhang (23771) Yuan Li (67017) |
| dc.date.none.fl_str_mv | 2025-11-26T05:14:49Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2025.1729349.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image_1_Association_between_spicy_food_consumption_and_the_risk_of_non-alcoholic_fatty_liver_disease_metabolic_dysfunction-associated_steatotic_liver_disease_and_liver_fibrosis_tif/30717632 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical and Sports Nutrition spicy food non-alcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease advanced liver fibrosis cohort study |
| dc.title.none.fl_str_mv | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | Introduction<p>Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed to explore the association between spicy food consumption and the risk of non-alcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis.</p>Methods<p>A total of 23,666 participants aged 25 to 60, free from NAFLD, MASLD, and liver fibrosis, were recruited from a multi-center physical examination database in Shijiazhuang, Hebei Province, China, between 2011 and 2024. Cox proportional hazards regression model assessed the association between spicy food consumption and incident NAFLD/MASLD and advanced liver fibrosis. Restricted cubic spline (RCS) functions estimated the dose–response relationship. Subgroup and sensitive analyses evaluated heterogeneity based on various characteristics, while sensitivity analyses tested the robustness of results.</p>Results<p>There were 42.2% of participants who reported consuming spicy food at least once per week. In this cohort study, a total of 7,965 patients with NAFLD and 7,311 patients with MASLD were identified after a median follow-up period of 12.6 years. Those who consumed spicy food more than once a week had a significantly lower risk of NAFLD/MASLD compared to non-consumers, indicating a dose–response relationship. However, this association was not observed in advanced liver fibrosis.</p>Conclusion<p>Weekly spicy food consumption was inversely associated with risk of incident NAFLD/MASLD, but not advanced liver fibrosis.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_817d5e2c088033142befe9244e6bccb0 |
| identifier_str_mv | 10.3389/fnut.2025.1729349.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30717632 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tifNa Zhao (112953)Huimin Liu (284624)Yan Wang (15435)Yun He (40953)Ning Zhang (23771)Yuan Li (67017)Clinical and Sports Nutritionspicy foodnon-alcoholic fatty liver diseasemetabolic dysfunction-associated steatotic liver diseaseadvanced liver fibrosiscohort studyIntroduction<p>Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed to explore the association between spicy food consumption and the risk of non-alcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis.</p>Methods<p>A total of 23,666 participants aged 25 to 60, free from NAFLD, MASLD, and liver fibrosis, were recruited from a multi-center physical examination database in Shijiazhuang, Hebei Province, China, between 2011 and 2024. Cox proportional hazards regression model assessed the association between spicy food consumption and incident NAFLD/MASLD and advanced liver fibrosis. Restricted cubic spline (RCS) functions estimated the dose–response relationship. Subgroup and sensitive analyses evaluated heterogeneity based on various characteristics, while sensitivity analyses tested the robustness of results.</p>Results<p>There were 42.2% of participants who reported consuming spicy food at least once per week. In this cohort study, a total of 7,965 patients with NAFLD and 7,311 patients with MASLD were identified after a median follow-up period of 12.6 years. Those who consumed spicy food more than once a week had a significantly lower risk of NAFLD/MASLD compared to non-consumers, indicating a dose–response relationship. However, this association was not observed in advanced liver fibrosis.</p>Conclusion<p>Weekly spicy food consumption was inversely associated with risk of incident NAFLD/MASLD, but not advanced liver fibrosis.</p>2025-11-26T05:14:49ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fnut.2025.1729349.s001https://figshare.com/articles/figure/Image_1_Association_between_spicy_food_consumption_and_the_risk_of_non-alcoholic_fatty_liver_disease_metabolic_dysfunction-associated_steatotic_liver_disease_and_liver_fibrosis_tif/30717632CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307176322025-11-26T05:14:49Z |
| spellingShingle | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif Na Zhao (112953) Clinical and Sports Nutrition spicy food non-alcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease advanced liver fibrosis cohort study |
| status_str | publishedVersion |
| title | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| title_full | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| title_fullStr | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| title_full_unstemmed | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| title_short | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| title_sort | Image 1_Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis.tif |
| topic | Clinical and Sports Nutrition spicy food non-alcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease advanced liver fibrosis cohort study |