Tryptophan Metabolism-Regulating Probiotics Alleviate Hyperuricemia by Protecting the Gut Barrier Integrity and Enhancing Colonic Uric Acid Excretion

Tryptophan Metabolism-Regulating Probiotics Alleviate Hyperuricemia by Protecting the Gut Barrier Integrity and Enhancing Colonic Uric Acid Excretion

The balance of gut microbiota affects uric acid synthesis and excretion, influencing the development of hyperuricemia. This study aimed to investigate the effects and mechanisms of probiotics on hyperuricemia and adenine- and potassium oxonate-induced colonic damage. After two months of gavage at 10...

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Bibliographic Details
Main Author: Qianxu Wang (7635668) (author)
Other Authors: Jiarui Liang (20296664) (author), Qianhui Zou (20296667) (author), Wenxiu Wang (635015) (author), Guiming Yan (7235252) (author), Rui Guo (134395) (author), Tian Yuan (693527) (author), Yutang Wang (495782) (author), Xuebo Liu (525911) (author), Zhigang Liu (265354) (author)
Published: 2024
Subjects:
Biochemistry
Medicine
Microbiology
Genetics
Physiology
Pharmacology
Biotechnology
Ecology
Immunology
Cancer
Inorganic Chemistry
Infectious Diseases
Chemical Sciences not elsewhere classified
xanthine oxidase activity
gut barrier integrity
76 ± 15
71 ± 56
22 ± 6
induced colonic damage
lactobacillus rhamnosus </
lactobacillus plantarum </
strains attenuated inflammatory
9 </ sup
probiotics alleviate hyperuricemia
lactobacillus </
colonic inflammatory
vitro </
probiotic strains
coprococcus </
colonic injury
two months
tryptophan metabolites
tryptophan metabolism
study aimed
riboflavin metabolism
propionic acid
preventing hyperuricemia
potential strategy
potassium oxonate
modulating tryptophan
hyperuricemia mice
findings suggest
beneficial bacteria
acetic acid
91 μmol
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