Investigations of cell death mechanisms induced by AZ10606120 treatment indicate involvement of RIPK1-independent TRADD mediated necroptosis.

<p><b>(a)</b> Gene expression of key genes associated with known downstream pathways of P2X7R activation in U251 cultures treated with AZ10606120 (15µM) relative to vehicle controls. AZ10606120 treatment induced downregulation of several key genes, demonstrating inhibition of P2X7R...

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1. autor:	Matthew Drill (22258391) (author)
Kolejni autorzy:	Liyen Katrina Kan (15944837) (author), Richard P. Sequeira (4420255) (author), Padmakrishnan Chorakode Jayakrishnan (22258394) (author), Martin Hunn (22258397) (author), Nigel C. Jones (12183968) (author), Terence J. O’Brien (9377660) (author), Mastura Monif (7342067) (author)
Wydane:	2025
Hasła przedmiotowe:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Pharmacology Immunology Developmental Biology Cancer Hematology Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified using rna sequencing tumour cell number single nucleotide polymorphism protein kinase 1 novel therapeutic target independent necroptosis pathway increased ldh release delineate downstream consequences channel conductance states cell death induced primary brain cancer div >< p purinergic receptor p2x7 u251 cell line inhibition induced cytotoxicity 2 </ sup glioblastoma </ p inhibit receptor function tradd mediated ripk1 primary mode receptor inhibition study examined significant changes pharmacological antagonist median survival interacting serine genes associated az10606120s acting annexin v aggressive form 17µm ). 15 months 001 ). 0001 ),
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Investigations of cell death mechanisms induced by AZ10606120 treatment indicate involvement of RIPK1-independent TRADD mediated necroptosis.

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