Table_1_The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.xlsx

Table_1_The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.xlsx

<p>Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to pred...

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Main Author: Zhe Wang (41178) (author)
Other Authors: Shing Wan Choi (8917562) (author), Nathalie Chami (9148338) (author), Eric Boerwinkle (36288) (author), Myriam Fornage (45591) (author), Susan Redline (113656) (author), Joshua C. Bis (7692986) (author), Jennifer A. Brody (7743146) (author), Bruce M. Psaty (7634144) (author), Wonji Kim (829493) (author), Merry-Lynn N. McDonald (8788601) (author), Elizabeth A. Regan (12019483) (author), Edwin K. Silverman (6856082) (author), Ching-Ti Liu (100170) (author), Ramachandran S. Vasan (7239080) (author), Rita R. Kalyani (9525049) (author), Rasika A. Mathias (8174124) (author), Lisa R. Yanek (8174148) (author), Donna K. Arnett (8174094) (author), Anne E. Justice (8136294) (author), Kari E. North (6733304) (author), Robert Kaplan (419010) (author), Susan R. Heckbert (12491014) (author), Mariza de Andrade (31845) (author), Xiuqing Guo (73591) (author), Leslie A. Lange (8661951) (author), Stephen S. Rich (12491017) (author), Jerome I. Rotter (7634114) (author), Patrick T. Ellinor (7743158) (author), Steven A. Lubitz (7743194) (author), John Blangero (28885) (author), M. Benjamin Shoemaker (4389976) (author), Dawood Darbar (181657) (author), Mark T. Gladwin (167745) (author), Christine M. Albert (9160433) (author), Daniel I. Chasman (7688885) (author), Rebecca D. Jackson (7802564) (author), Charles Kooperberg (18693) (author), Alexander P. Reiner (8174154) (author), Paul F. O’Reilly (10960881) (author), Ruth J. F. Loos (6733301) (author)
Published: 2022
Subjects:
Endocrinology
Reproduction
Cell Metabolism
polygenic risk score
rare variants
obesity risk
burden score
PRS-CS
lassosum
C+T
BMI - body mass index
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