A Small Molecule Impedes the Aβ1–42 Tetramer Neurotoxicity by Preserving Membrane Integrity: Microsecond Multiscale Simulations

Amyloid-β (Aβ1–42) peptides aggregated into plaques deposited in the brain are the main hallmark of Alzheimer’s disease (AD), a social and economic burden worldwide. In this context, insoluble Aβ1–42 fibrils are the main components of plaques. The recent...

Full description

Saved in:

Bibliographic Details
Main Author:	Subramanian Boopathi (8733639) (author)
Other Authors:	Ramón Garduño-Juárez (10702425) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Medicine Cell Biology Neuroscience Pharmacology Immunology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified unrestricted conformational flexibility reduced conformational changes positively charged residues explicit solvent model economic burden worldwide bottom bilayer leaflet bilayer surface due bilayer hydrophobic region small molecule impedes mounting evidence envisages m30 molecules bind affected mice memory aa )/ coarse membrane phosphate groups membrane bilayer organization deep tetramer penetration conformational stable aβ preserving membrane integrity oligomers ’ interactions cg md simulations membrane bilayer termed m30 severely affected experimental evidence aβ molecule oligomer ’ alzheimer ’ dmpc bilayer μs aa vivo </ vitro </ tetramer structure tetramer penetrates tetramer neurotoxicity tetramer dissociation soluble aβ significantly perturb rigid structure recent trials observations support membrane contacts md simulations main hallmark main components insoluble aβ improving ad hydrogen bonds findings suggest fibril interactions enhanced rigidity embedded aβ demanding tasks close contact associated complex ad ),
Tags:	Add Tag No Tags, Be the first to tag this record!

A Small Molecule Impedes the Aβ<sub>1–42</sub> Tetramer Neurotoxicity by Preserving Membrane Integrity: Microsecond Multiscale Simulations

Similar Items