Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia
<p>NKCEs enhance NK-cell activity against MHH-CALL-4 cell line. CD107a expression and IFNγ production by resting NK cells from healthy donors (<i>n</i> = 3–6) cocultured for 6 hours with MHH-CALL-4 cells in the absence or presence of CD19-NKCEs, CD20-NKCEs, or the control molecules...
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2025
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| _version_ | 1849927631563128832 |
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| author | Natalia Colomar-Carando (14611340) |
| author2 | Laurent Gauthier (15129623) Pietro Merli (15129626) Fabrizio Loiacono (5306981) Paolo Canevali (332990) Michela Falco (368897) Federica Galaverna (8825531) Benjamin Rossi (15129629) Frédéric Bosco (15129632) Mélody Caratini (15129635) Maria Cristina Mingari (8409327) Franco Locatelli (15127797) Eric Vivier (48284) Raffaella Meazza (7179467) Daniela Pende (15129638) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Natalia Colomar-Carando (14611340) Laurent Gauthier (15129623) Pietro Merli (15129626) Fabrizio Loiacono (5306981) Paolo Canevali (332990) Michela Falco (368897) Federica Galaverna (8825531) Benjamin Rossi (15129629) Frédéric Bosco (15129632) Mélody Caratini (15129635) Maria Cristina Mingari (8409327) Franco Locatelli (15127797) Eric Vivier (48284) Raffaella Meazza (7179467) Daniela Pende (15129638) |
| author_role | author |
| dc.creator.none.fl_str_mv | Natalia Colomar-Carando (14611340) Laurent Gauthier (15129623) Pietro Merli (15129626) Fabrizio Loiacono (5306981) Paolo Canevali (332990) Michela Falco (368897) Federica Galaverna (8825531) Benjamin Rossi (15129629) Frédéric Bosco (15129632) Mélody Caratini (15129635) Maria Cristina Mingari (8409327) Franco Locatelli (15127797) Eric Vivier (48284) Raffaella Meazza (7179467) Daniela Pende (15129638) |
| dc.date.none.fl_str_mv | 2025-11-25T13:42:41Z |
| dc.identifier.none.fl_str_mv | 10.1158/2326-6066.30710200 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_2_from_Exploiting_Natural_Killer_Cell_Engagers_to_Control_Pediatric_B-cell_Precursor_Acute_Lymphoblastic_Leukemia/30710200 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Immuno-oncology Hematological Cancers Leukemias Immunology NK cells Immunotherapy Stem cell transplantation |
| dc.title.none.fl_str_mv | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>NKCEs enhance NK-cell activity against MHH-CALL-4 cell line. CD107a expression and IFNγ production by resting NK cells from healthy donors (<i>n</i> = 3–6) cocultured for 6 hours with MHH-CALL-4 cells in the absence or presence of CD19-NKCEs, CD20-NKCEs, or the control molecules (IC-NKp46-NKCE, IC-NKp30-NKCE) at 10<sup>−2</sup> μg/mL and 10<sup>0</sup> μg/mL. <b>A,</b> Flow cytometry of a representative experiment is shown. Numbers indicate the percentage of cells in each quadrant. CD107a expression (<b>B</b>) and IFNγ production (<b>C</b>) were performed in 3–6 independent experiments. Bars show mean ± SEM. Statistical significance: *, <i>P</i> ≤ 0.05; **, <i>P</i> ≤ 0.01; ***, <i>P</i> ≤ 0.001. Two-way ANOVA followed by Tukey test was used to calculate statistical differences among the indicated NKCEs within each concentration. Mann–Whitney test was used to compare each NKCE at the two indicated concentrations.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_854b2309b5f0086ea38f79014a0527e0 |
| identifier_str_mv | 10.1158/2326-6066.30710200 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30710200 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic LeukemiaNatalia Colomar-Carando (14611340)Laurent Gauthier (15129623)Pietro Merli (15129626)Fabrizio Loiacono (5306981)Paolo Canevali (332990)Michela Falco (368897)Federica Galaverna (8825531)Benjamin Rossi (15129629)Frédéric Bosco (15129632)Mélody Caratini (15129635)Maria Cristina Mingari (8409327)Franco Locatelli (15127797)Eric Vivier (48284)Raffaella Meazza (7179467)Daniela Pende (15129638)CancerImmuno-oncologyHematological CancersLeukemiasImmunologyNK cellsImmunotherapyStem cell transplantation<p>NKCEs enhance NK-cell activity against MHH-CALL-4 cell line. CD107a expression and IFNγ production by resting NK cells from healthy donors (<i>n</i> = 3–6) cocultured for 6 hours with MHH-CALL-4 cells in the absence or presence of CD19-NKCEs, CD20-NKCEs, or the control molecules (IC-NKp46-NKCE, IC-NKp30-NKCE) at 10<sup>−2</sup> μg/mL and 10<sup>0</sup> μg/mL. <b>A,</b> Flow cytometry of a representative experiment is shown. Numbers indicate the percentage of cells in each quadrant. CD107a expression (<b>B</b>) and IFNγ production (<b>C</b>) were performed in 3–6 independent experiments. Bars show mean ± SEM. Statistical significance: *, <i>P</i> ≤ 0.05; **, <i>P</i> ≤ 0.01; ***, <i>P</i> ≤ 0.001. Two-way ANOVA followed by Tukey test was used to calculate statistical differences among the indicated NKCEs within each concentration. Mann–Whitney test was used to compare each NKCE at the two indicated concentrations.</p>2025-11-25T13:42:41ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/2326-6066.30710200https://figshare.com/articles/figure/Figure_2_from_Exploiting_Natural_Killer_Cell_Engagers_to_Control_Pediatric_B-cell_Precursor_Acute_Lymphoblastic_Leukemia/30710200CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307102002025-11-25T13:42:41Z |
| spellingShingle | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia Natalia Colomar-Carando (14611340) Cancer Immuno-oncology Hematological Cancers Leukemias Immunology NK cells Immunotherapy Stem cell transplantation |
| status_str | publishedVersion |
| title | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| title_full | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| title_fullStr | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| title_short | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| title_sort | Figure 2 from Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia |
| topic | Cancer Immuno-oncology Hematological Cancers Leukemias Immunology NK cells Immunotherapy Stem cell transplantation |