Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers

Immunomodulatory drugs (IMiDs) are widely utilized therapies in multiple hematological cancers; however, their clinical application is frequently constrained by drug resistance. Here, though screening of diverse cereblon (CRBN) binders, comprehensive structure–activity relationships (SAR) analyses a...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক:	Ting Wei (113015) (author)
অন্যান্য লেখক:	Shiyang Sun (588807) (author), Xiaotong Hu (558839) (author), Pengli Wei (14641202) (author), Zhiya Fan (9411634) (author), Jian Yan (49839) (author), Yalei Wang (669779) (author), Zhenze Qi (21726058) (author), Changkai Jia (21726052) (author), Yaqiu Mao (21726055) (author), Tingting Yang (166111) (author), Xu Cai (5326745) (author), Bingkun Li (9752768) (author), Zhiyuan Zhao (1400806) (author), Min Qiao (111120) (author), Yaxin Zou (21726061) (author), Weijie Qin (1694185) (author), Xuesong Feng (754835) (author), Hongzhou Shang (21929961) (author), Pengyun Li (2685118) (author), Zhibing Zheng (9716361) (author), Song Li (65582) (author)
প্রকাশিত:	2025
বিষয়গুলি:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Infectious Diseases Virology Space Science Chemical Sciences not elsewhere classified widely utilized therapies promising therapeutic candidate multiple hematological cancers marked synergistic effects admirable pharmacokinetic properties systematic degradation profiling overcame acquired resistance diffuse large b 22 </ b 50 </ sub 3 degrader featuring hematological cancer treatment dlbcl cancer cells cancer cells targeted degradation drug resistance tyrosine kinase though screening range ic phthalazinone scaffold orally administered nanomolar dc frequently constrained findings establish diverse cereblon dependent manner demonstrated nanomolar clinical application cell lymphoma bruton ’ broader applicability aml ), 3 degraders
ট্যাগগুলো:	ট্যাগ যুক্ত করুন কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers

অনুরূপ উপাদানগুলি