Additional file 3 of Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide

Additional file 3 of Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide

Additional file 3: Development of novel AMs From the phage library screen, the Fab-based AM candidates were identified. To test them, (A.1) a high throughput screening was conducted, where AdCAR-T, directed against a tag on the newly generated binders, were repeatedly exposed to OCI-AML-2 to test th...

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Main Author: Beate Kristmann (18178291) (author)
Other Authors: Niels Werchau (21802719) (author), Lakshmi Suresh (6613076) (author), Elisabeth L. Pezzuto (21802722) (author), Sophia Scheuermann (18178288) (author), Simon Krost (18542928) (author), Karin Schilbach (4831755) (author), Moustafa Moustafa-Oglou (21802725) (author), Anna-Sophia Mast (21802728) (author), Miriam Droste (8843636) (author), André Felsberger (21802731) (author), Lukas Kiefer (21802734) (author), Pierre Abramowski (542289) (author), Lars Zender (698425) (author), Joerg Mittelstaet (1885666) (author), Christian M. Seitz (18178309) (author)
Published: 2025
Subjects:
Immunology
SCLC
CD276
Immunotherapy
AdCAR-T
Fab-based adapter molecule
Fratricide
In vivo solid tumor targeting
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