Steric Hindrance-Driven Access to 3,4,7-Trihydro-1,2-oxaphosphepine 2‑Oxides from Vinyloxiranes and Phosphoryl Diazomethanes

Steric Hindrance-Driven Access to 3,4,7-Trihydro-1,2-oxaphosphepine 2‑Oxides from Vinyloxiranes and Phosphoryl Diazomethanes

Various 3,4,7-trihydro-1,2-oxaphosphepine 2-oxides are synthesized in satisfactory to excellent yields from 2-aryl-2-vinyloxiranes and in situ-generated phosphenes from phosphoryl diazomethanes via the phosphene-induced and steric hindrance-driven ring expansion of vinyloxiranes. The reaction is an...

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Bibliographic Details
Main Author: Fuchen Li (22476499) (author)
Other Authors: Yinqiao Wang (18186518) (author), Jiaxi Xu (681245) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Genetics
Molecular Biology
Physiology
Evolutionary Biology
Marine Biology
Virology
Computational Biology
Environmental Sciences not elsewhere classified
unprecedented synthetic strategy
phosphoryl diazomethanes via
high atom economy
featuring ring expansion
driven ring expansion
fast reaction rate
driven access
steric hindrance
separable diastereomers
oxide derivatives
generated phosphenes
excellent yields
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