Steric Hindrance-Driven Access to 3,4,7-Trihydro-1,2-oxaphosphepine 2‑Oxides from Vinyloxiranes and Phosphoryl Diazomethanes

Various 3,4,7-trihydro-1,2-oxaphosphepine 2-oxides are synthesized in satisfactory to excellent yields from 2-aryl-2-vinyloxiranes and in situ-generated phosphenes from phosphoryl diazomethanes via the phosphene-induced and steric hindrance-driven ring expansion of vinyloxiranes. The reaction is an...

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Bibliographic Details
Main Author:	Fuchen Li (22476499) (author)
Other Authors:	Yinqiao Wang (18186518) (author), Jiaxi Xu (681245) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Genetics Molecular Biology Physiology Evolutionary Biology Marine Biology Virology Computational Biology Environmental Sciences not elsewhere classified unprecedented synthetic strategy phosphoryl diazomethanes via high atom economy featuring ring expansion driven ring expansion fast reaction rate driven access steric hindrance separable diastereomers oxide derivatives generated phosphenes excellent yields
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Steric Hindrance-Driven Access to 3,4,7-Trihydro-1,2-oxaphosphepine 2‑Oxides from Vinyloxiranes and Phosphoryl Diazomethanes

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