Effect of overexpression of eEF2 on growth of cells containing mutations in Hsp90.

<p>A plasmid expressing wild-type His-eEF2 or empty vector was transformed into the strains as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011508#pgen.1011508.s004" target="_blank">S2 Fig</a>. Transformants were grown overnight...

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Bibliographic Details
Main Author:	Melody D. Fulton (1339137) (author)
Other Authors:	Danielle J. Yama (20405131) (author), Ella Dahl (20405134) (author), Jill L. Johnson (10879577) (author)
Published:	2024
Subjects:	Biochemistry Medicine Genetics Molecular Biology Biological Sciences not elsewhere classified unique posttranslational modification protein homeostasis relies newly synthesized proteins different cochaperone mutation regulating eef2 function affected eef2 accumulation two distinct roles gene encoding hgh1 div >< p assisting protein folding enabling accurate translation also negatively affected yeast hsp90 mutants yeast eef2 negatively impacted hsp90 mutants accurate translation cochaperone mutations human eef2 eef2 folding vivo </ state levels results provide reduced steady recently shown promotes gtp partially rescued one mutant one group mimic disease hsp90 contributes diphtheria toxin altered sensitivity
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Effect of overexpression of eEF2 on growth of cells containing mutations in Hsp90.

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