The PPIs network of 111 common targets and identification of hub targets.

The PPIs network of 111 common targets and identification of hub targets.

<p>(A) PPIs network map; (B) Centrality of network nodes displayed by scatter plot. Five hub targets were defined by betweenness ≥ 500 and degree ≥ 30.</p>

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Bibliographic Details
Main Author:	Xing Li (134367) (author)
Other Authors:	Kaiqi Ren (20774060) (author), Michal R. Baran (22367067) (author), Juan Tang (437969) (author), Le Wang (165105) (author), Gabriel Mbuta Tchivelekete (13228012) (author), Yi Guo (35817) (author), Yang Bai (198601) (author), Weijian Yan (12151821) (author), Xinhua Shu (339216) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Pharmacology Immunology Marine Biology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified global health challenge eight active components also reversely screened 293 cells exposed potential mechanism involving used network pharmacology five hub targets protein interaction network xlink "> sepsis inflammatory signaling pathways underlying therapeutic mechanism therapeutic mechanism underlying mechanisms disease targets commonly used protein levels protein level analyzing protein vivo </ vitro </ treating sepsis remain elusive preferentially bound pharmacological basis molecular docking injection prepared highest affinity high mortality gene ontology core drug clinical treatment
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