Increased expression of genes associated with the innate immune response and inflammation, and reduced expression of genes associated with T and NK cell functions in patients on intensive phase treatment.

<p>(a) Principal component analysis (PCA) of gene expression data derived from RNA-sequencing. Principal component (PC1) and PC2 accounts for 26% and 19%, respectively, variance of dataset. Each dot represents one patient from the study; different colours represent different phases of MABC-PD...

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Bibliographic Details
Main Author:	Ayesa Syenina (12699902) (author)
Other Authors:	Yi Hern Tan (20968443) (author), Danny Jian Hang Tng (20968446) (author), Sandy Xue Qi Sim (20968449) (author), Valerie Shyn Yun Chew (20968452) (author), Jia Xin Yee (12699914) (author), Eugenia Ziying Ong (20968455) (author), Eng Eong Ooi (6861014) (author), Jenny Guek Hong Low (17836739) (author), Dorothy Hui Lin Ng (17836733) (author)
Published:	2025
Subjects:	Medicine Genetics Molecular Biology Immunology Cancer Infectious Diseases receiver operating characteristic mycobacterium abscessus </ ifn &# 947 findings provide insights clinically relevant indicators underlying lung disease often relapsing disease complex pulmonary disease 45 plasma proteins 45 plasma cytokines identifying reliable prognosticators guide treatment decisions especially among individuals chronic pulmonary conditions disease progression plasma levels associated cytokines xlink "> watchful waiting useful biomarkers treatment phases thereby aiding suggesting recruitment significantly reduced sequencing revealed related symptoms reduced abundance innate immune inflammatory responses infection sites immune profiles healthy controls genes related genes associated distinguishing infection cytokine signatures curve analysis could serve considerable morbidity chemokines profiled associated genes
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Increased expression of genes associated with the innate immune response and inflammation, and reduced expression of genes associated with T and NK cell functions in patients on intensive phase treatment.

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