Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery

While sulfoximines are nowadays a well established functional group for medicinal chemistry, the properties of sulfilimines are significantly less well studied, and no sulfilimine has progressed to the clinic to date. In this account, the physicochemical and in vitro properties of sulfilimines are r...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Nathaniel S. Greenwood (13863486) (author)
مؤلفون آخرون:	Zachary W. Boyer (18856800) (author), Jonathan A. Ellman (610362) (author), Christian Gnamm (2305375) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Pharmacology Developmental Biology Cancer Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified traditional functional groups physiologically relevant conditions medicinal chemist ’ vitro parameters relevant real drug scaffolds >- cyclopropyl ,< medicinal chemistry toolbox medicinal chemistry drug discovery >- di vitro properties two series reduced permeability potentially valuable often beneficial metabolic stability hne inhibitors highly polar far neglected containing analogs configurationally stable based pharmacophores
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery

مواد مشابهة