Altered Abundance of Barrier-Related Proteins in Brain Microvascular Endothelial Cells of the GL261 Mouse Model of Glioblastoma

Glioblastoma multiform (GBM) is a brain cancer that has limited treatment options and a high fatality rate, due in part to limited access of chemotherapeutics to the tumor resulting from the restrictive nature of the blood-brain barrier (BBB). The present study characterized the proteome of endothel...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক:	Liam M Koehn (22456354) (author)
অন্যান্য লেখক:	Diana Cao (3765217) (author), Joel R Steele (18978233) (author), Angela Rigopoulos (1366590) (author), Ingrid JG Burvenich (9650555) (author), Han Chung-Lee (22456357) (author), Erwin Tanuwidjaya (14293787) (author), Ralf B Schittenhelm (11548630) (author), Andrew M Scott (9650561) (author), Hui K Gan (9650552) (author), Joseph A Nicolazzo (18320985) (author)
প্রকাশিত:	2025
বিষয়গুলি:	Biophysics Biochemistry Medicine Cell Biology Genetics Neuroscience Physiology Pharmacology Biotechnology Immunology Developmental Biology Cancer present study characterized nonvascular patterning within mediated transcellular transport isolated using magnetic high fatality rate glioblastoma glioblastoma multiform g ., long activated cell sorting >- transferase a4 tight junction proteins significantly lower abundance limited treatment options identify putative transporters endothelial cells forming brain endothelial cells gl261 mouse model enhance drug delivery mouse model related proteins limited access drug transporters drug delivery altered abundance brain cancer tumor resulting restrictive nature receptors may metabolizing enzymes glioma 261 future therapeutics
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Altered Abundance of Barrier-Related Proteins in Brain Microvascular Endothelial Cells of the GL261 Mouse Model of Glioblastoma

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