2A<sup>pro</sup> is the key viral protease responsible for the suppression of type I interferon signaling.

<p>(A) HeLa-R19 cells were infected at an MOI of 10 and lysed at 2, 4, 6, 8, 10 and 16 hpi. Total RNA was analyzed by RT-qPCR for IFN-β, IFIT1, viral RNA (vRNA) and actin. IFN-β, IFIT1 and vRNA levels were calculated as fold induction compared to levels in mock-infected cells, after correction...

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المؤلف الرئيسي:	Jelle G. Schipper (16866034) (author)
مؤلفون آخرون:	Chiara Aloise (8374950) (author), Sereina O. Sutter (13029037) (author), Marleen Zwaagstra (9611632) (author), Arno L.W. van Vliet (22139247) (author), Rana Abdelnabi (2145439) (author), Bob Ignacio (6836786) (author), Kimberly M. Bonger (1856443) (author), Dagmar Roelofs (22139250) (author), Judith M.A. van den Brand (22139253) (author), Richard W. Wubbolts (3797863) (author), Lucas J.M. Bruurs (22139256) (author), Hendrik Jan Thibaut (550169) (author), Johan Neyts (55640) (author), Marvin E. Tanenbaum (17093939) (author), Frank J. M. van Kuppeveld (7252571) (author)
منشور في:	2025
الموضوعات:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Ecology Immunology Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified subverting antiviral responses induced restriction factors host mrna translation enteroviruses dramatically remodel disturbing nucleocytoplasmic transport incoming viral rna surrogate infection systems catalytically inactivate 2a viral 2a protease pro </ sup div >< p viral proteins vitro </ efficient infection inactive 2a virus context t2a sequence studied mostly severely attenuated p2 junction overcoming ifn multifaceted role initial round ifn response favorable environment ectopic overexpression critical role coxsackievirus b3 cellular infrastructure cell lines allowing us advanced single
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2A<sup>pro</sup> is the key viral protease responsible for the suppression of type I interferon signaling.

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