PMS activated xCT/GPX4 pathway in T2DM mice.

PMS activated xCT/GPX4 pathway in T2DM mice.

<p>(a-c) PMS increased GSH content (a), decreased GSSG level (b), and elevated the GSH/GSSG ratio (c) in pancreatic tissue. (d-f) RT-qPCR results showed that PMS up-regulated the mRNA expression of <i>Slc7a11</i> (d), <i>Slc3a2</i> (e), and <i>Gpx4</i> (f)....

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מחבר ראשי:	Hongmin Zhao (20710544) (author)
מחברים אחרים:	Renlin Li (21439962) (author), Xuan Guo (1791202) (author), Jingrui Kang (21578315) (author), Huajun Li (8309904) (author), Xiaoyun Wang (148866) (author), Yuansong Wang (14103603) (author), Huantian Cui (5798996) (author), Shuquan Lv (11897978) (author), Weibo Wen (8115296) (author), Zhongyong Zhang (11887698) (author)
יצא לאור:	2025
נושאים:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Immunology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified mechanisms remain unclear pancreatic &# 946 upregulated factors linked t2dm ), may improving t2dm outcomes pancreatic islet β alleviating cellular damage ferroptosis inhibitor ferrostatin div >< p gpx4 inhibitor rsl ferroptosis inhibitor fer pms alleviated hg t2dm via activation gpx4 pathway modulation pancreatic β factors associated t2dm mice gpx4 pathway gpx4 axis cells via tissue damage induced damage induce damage diminish damage cell damage suppressing ferroptosis suppressed ferroptosis reduced ferroptosis inhibiting ferroptosis inhibit ferroptosis vivo </ vitro </ shows promise positive control pms exhibited palmitic acid lipid peroxidation key pathology glutamate transporter findings revealed beneficial impacts 3 attenuated
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