Analysis results for mouse embryonic fibroblast (MEF)-to-neuron data.

Analysis results for mouse embryonic fibroblast (MEF)-to-neuron data.

<p>(A) The trajectory of the directed network flow entropy (DNFE) score throughout the MEF-to-neuron reprogramming timeline is marked by notable escalation at day 20, signifying a tipping point that heralds a critical phase in the cellular transition. (B) The DNFE landscape of dynamic network...

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Bibliographic Details
Main Author: Xueqing Peng (10678527) (author)
Other Authors: Rui Qiao (458542) (author), Peiluan Li (6156950) (author), Luonan Chen (21547) (author)
Published: 2025
Subjects:
Biophysics
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Cancer
Infectious Diseases
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
Information Systems not elsewhere classified
xlink "> typically
outperforms existing methods
identified &# 8220
dynamic biological processes
delay disastrous outcomes
six real datasets
one stable state
detecting tipping points
dynamic network biomarkers
method &# 8217
including three single
identifying critical states
critical state
tipping point
cell datasets
driving network
directed network
usually overlooked
scale data
sample data
numerical simulations
implemented based
dimensional small
cell rna
cell data
bulk data
blood dataset
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