Analysis results for mouse embryonic fibroblast (MEF)-to-neuron data.
<p>(A) The trajectory of the directed network flow entropy (DNFE) score throughout the MEF-to-neuron reprogramming timeline is marked by notable escalation at day 20, signifying a tipping point that heralds a critical phase in the cellular transition. (B) The DNFE landscape of dynamic network...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | <p>(A) The trajectory of the directed network flow entropy (DNFE) score throughout the MEF-to-neuron reprogramming timeline is marked by notable escalation at day 20, signifying a tipping point that heralds a critical phase in the cellular transition. (B) The DNFE landscape of dynamic network biomarkers (DNBs) during the MEF-to-neuron transition reveals a pronounced uptick in the DNFE score at day 20, which is indicative of a tipping point. (C) The temporal dynamics of DNBs throughout the MEF-to-neuron transition are characterized by a discernible pattern of change, with the critical state detectable at day 20. (D) Top 20 upstream hub transcription factors are able to regulate 89% of the identified DNB genes at day 20. (E) The results of the regulatory association between the top 20 transcription factors are shown as a network. (F) The top five transcription factors (TFs) identified using each library, with these TFs represented along the columns and the query genes along the rows. The entries within this matrix are populated based on whether a query gene is present or absent within the target gene set of a library TF at the second tipping point.</p> <p>(JPG)</p> |
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