Sensitivity vs Competing Proton Transfer Reactions: Addressing Key Parameters of Ion Chemistry in Ion Mobility Spectrometry

Ion mobility spectrometers (IMS) are widely used in various gas sensing applications due to their high sensitivity and rapid analysis times. However, in complex gas mixtures, reactions between the protonated target analyte and interfering species can lead to discrimination of analytes with low gas b...

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Bibliographic Details
Main Author:	Christoph Schaefer (9357141) (author)
Other Authors:	Stefan Zimmermann (1694173) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Infectious Diseases Space Science Chemical Sciences not elsewhere classified rapid analysis times protonated target analyte complex gas mixtures complex chemical backgrounds addressing key parameters low gas basicity key operating parameters ion suppression caused thereby enhancing sensitivity minimize competing reactions detecting target analytes decreasing operating pressure operating pressure low pressure ion chemistry reducing sensitivity increase sensitivity high sensitivity widely used results demonstrate reaction time promising strategies operating ims kinetic model interfering species instrumental design high concentrations
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Sensitivity vs Competing Proton Transfer Reactions: Addressing Key Parameters of Ion Chemistry in Ion Mobility Spectrometry

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