TBK1 activation involves Gal8 but not Gal3.

TBK1 activation involves Gal8 but not Gal3.

<p>(<b>A</b>) U2OS cells were transfected with a control siRNA (siCTRL) or siRNA targeting either Gal3 (siGal3) (<b>top panel</b>) or Gal8 (siGal8) (<b>bottom panel</b>) and analyzed by western blot using anti Gal3 and Gal8 antibodies, respectively. (<b&g...

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Bibliographic Details
Main Author:	Noémie Pied (13124440) (author)
Other Authors:	Coralie F. Daussy (13124443) (author), Zoé Denis (13124446) (author), Jessica Ragues (13124449) (author), Muriel Faure (3743779) (author), Richard Iggo (292501) (author), Mario P. Tschan (13124452) (author), Benoit Roger (1451914) (author), Fabienne Rayne (181771) (author), Harald Wodrich (7272) (author)
Published:	2022
Subjects:	Microbiology Cell Biology Physiology Immunology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified study thus highlights important vaccine platform sterile lysosomal damage tbk1 require detection places tbk1 early promotes subsequent autophagy classical autophagy receptors adenoviral endosome penetration induced membrane damage endosomal membrane lysis enter host cells endosomal membrane membrane damage important role host cell adenoviral entry membrane alterations cells perceive cells mount kinase tbk1 implicate tbk1 functional autophagy autophagy induction activating autophagy viral infections vector derivatives take control previously showed phosphorylated form penetration site pathway leading occur independently galectin 8 endocytosis followed danger signals comparing adenovirus broader range bacterial invasion adenovirus mutant adenovirus infection
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