YFV-Asibi cap0 grows slower and to reduced viral titers in secondary tissues after intrathoracic injection.

<p>A, B) <i>Aedes aegypti</i> mosquitoes were intrathoracically infected with 300 PFU YFV-Asibi cap1 or cap0. At 0, 3, and 7 days post-injection, viral genome copies were determined in the carcasses (mosquitoes w/o legs and wings) (A) and in the legs plus wings (B). The blue lines...

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Bibliographic Details
Main Author:	Anja vom Hemdt (19787189) (author)
Other Authors:	Alexandra L. Thienel (19787192) (author), Katrin Ciupka (14712151) (author), Janett Wieseler (19787195) (author), Hannah M. Proksch (19787198) (author), Martin Schlee (10672) (author), Beate M. Kümmerer (17748614) (author)
Published:	2024
Subjects:	Microbiology Cell Biology Molecular Biology Immunology Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified several mutations across largely diminished dissemination div >< p aedes albopictus </ aedes aegypti </ >- derived c6 viral growth analyses analyses using chimeras viral genome resulting viral genome accompanied type asibi strain structural protein ns5 rna sensor rig various mosquito cells mosquito cells revealed asibi cap0 attenuation secondary tissues compared unmethylated cap0 structure asibi cap1 correlates lower infection rates yfv cap0 viruses 17d cap0 replication mosquito cells cap0 viruses asibi cap0 secondary tissues rna genome cap0 structure asibi cap1 cap1 structure replication analyses yfv ns5 asibi suggest 36 cells 17d genome oral infection lower extent intrathoracic infection vaccine 17d synergistic effect striking difference results suggest restricted replication orthoflaviviruses encodes inhibition differed entirely dispensable distinct downregulation decreased amounts completely blocked analyzed whether also suppressed
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YFV-Asibi cap0 grows slower and to reduced viral titers in secondary tissues after intrathoracic injection.

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