Hemodynamic effects of WT BMP9 in rats.

(A) Continuous hemodynamic measurement of SBP over 48h after a single SC dose of WT BMP9 (3-100 µg/kg) in Su/Hx rats (n = 6). (B) HR changes quantified at 6h timepoint post dose in Su/Hx rats (n = 6). (C) SBP changes after repeat dose...

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المؤلف الرئيسي:	Tobias G. Schips (21799838) (author)
مؤلفون آخرون:	Karl W. Kavalkovich (21799841) (author), Lai-ming Yung (21799844) (author), Salam Ibrahim (10009779) (author), Makhosi Edmondson (21799847) (author), Zhigang Hong (5448872) (author), Chin-hu Huang (21799850) (author), Simon Hinke (21799853) (author), Xinkang Wang (10765051) (author), Andrea R. Nawrocki (13133479) (author), Annmarie Winkis (18315258) (author), Jinquan Luo (21799856) (author), Iman Farasat (2173399) (author), Brian Geist (21408943) (author), Yang Wang (5921) (author), Russell Bialecki (21799859) (author), Jey R. Jeyaseelan (21799862) (author), David R. Bauman (21799865) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Immunology Cancer Biological Sciences not elsewhere classified xlink "> given unwanted bone formation resulting vascular remodeling clinical studies demonstrated alk1 receptor complexes 500 &# 181 wild type bmp9 bmp9 treatment could bmp9 supplementation therapy alk1 mediated signaling right ventricular hypertrophy high arterial pressure examine disease reversal dose limiting toxicity wt bmp9 failed pulmonary hypertension served pulmonary hypertension indicated pulmonary arterial hypertension hypoxia rat model decreased heart rate human wt bmp9 bmpr2 signaling pathway wt bmp9 pulmonary hypertension pulmonary pressure human bmp9 actr2 signaling right side limiting effects debilitating disease human systems vivo </ vitro </ therapeutic window therapeutic efficacy sugen 5416 significant change rat bmpr2 progenitor cells previous pre osteogenic variant mutant variant findings including exogenous administration escalating doses enhances bmpr2 endothelial cells cynomolgus monkey characterize efficacy
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Hemodynamic effects of WT BMP9 in rats.

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