Figure 5 from M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

Figure 5 from M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer

<p><i>In vivo</i> antitumor activity of M4205 in xenograft models expressing oncogenic <i>KIT</i> mutations. Tumor bearing mice were treated daily with M4205 by oral gavage at doses indicated (10 mice per group). Body weight of mice was measured daily, and tumor growth...

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Glavni avtor: Christina Esdar (16424072) (author)
Drugi avtorji: Nina Linde (16424066) (author), Andreas Blum (21644608) (author), Hanno Schieferstein (21644611) (author), Christine Drechsler (16424069) (author), Eva Sherbetjian (21644614) (author), Carl Petersson (21644617) (author), Edith Ross (21644620) (author), Birgitta Leuthner (17885856) (author), Ulrich Grädler (21644623) (author), Dieter Dorsch (21644626) (author), Andree Blaukat (15088980) (author)
Izdano: 2025
Teme:
Cancer
Cancer Biology
Therapeutic Research and Development
Oncogenes & Tumor Suppressors
Oncogenes
Sarcomas
Small Molecule Agents
Kinase inhibitors
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