ABT199 inhibits ALK mutant kinase activity and decreases it phosphorylation.

A) ALK kinase activity curve shows that ABT199 is able to inhibit ALK kinase activity (IC50: 5.5 μM). B) Graph bars show Anova and tukey test of pALK expression normalized to ALK. C) Heatmap show pALK expressions normalized after 48 hours treatment by ALKi or ABT199,...

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Bibliographic Details
Main Author:	Richard Junior Zapata Dongo (17912565) (author)
Other Authors:	Diletta Fontana (18221765) (author), Luca Mologni (114485) (author), Juan Enrique Faya Castillo (17912562) (author), Stefany Fiorella Infante Varillas (17912571) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Immunology Cancer Hematology Infectious Diseases Biological Sciences not elsewhere classified secondary therapeutic target potential therapeutic target anaplastic lymphoma kinase cell death regulation selective bcl2 inhibitor overcome resistance caused div >< p 5 μm ). apoptotic protein bcl2 g1202r cell models alk cell models cell proliferation protein involved targets bcl2 inhibit bcl2 bcl2 targeting bcl2 expression wide range vitro </ synergistic effects significant decrease regulate phosphorylation oncoprotein plays line crizotinib findings indicate crucial role constitutive phosphorylation also binds alk phosphorylation alk mutants alk inhibitors alk gene
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ABT199 inhibits ALK <sup>mutant</sup> kinase activity and decreases it phosphorylation.

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