cey-1 loss-of-function mutants as well as worms with neuron-specific rescue of cey-1 (cey-1(rrr12); rab-3p::CEY-1) have no deficits in butanone sensing or motility, and neuron-specific rescue of cey-1 restores learning and memory ability to wild-type levels.

(A) Naïve chemotaxis towards 10% butanone prior to behavioral conditioning does not significantly differ between wild-type animals, cey-1(ok1805), and cey-1(rrr12) mutants. n = 15 per genotype. (B) Baseline chemosensation for butanone at an attractive c...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ashley N. Hayden (19871128) (author)
مؤلفون آخرون:	Katie L. Brandel (19871131) (author), Edward W. Pietryk (5777888) (author), Paul R. Merlau (19871134) (author), Priyadharshini Vijayakumar (19871137) (author), Emily J. Leptich (19871140) (author), Elizabeth S. Gaytan (19871143) (author), Meredith I. Williams (19871146) (author), Connie W. Ni (19871149) (author), Hsiao-Tuan Chao (4454008) (author), Jill A. Rosenfeld (9606199) (author), Rachel N. Arey (19871152) (author)
منشور في:	2024
الموضوعات:	Biochemistry Neuroscience Pharmacology Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified test evolutionary conservation single nucleotide variants potential new source behavioral screening reveals potential functional significance leveraging human datasets ></ u >< reveal memory regulators div >< p x </ u b </ u identifies ybx dysfunction binding protein required 20 conserved rbps u >< unknown significance rbp dysfunction human genome conserved residue binding proteins ybxs </ ybx3 </ legans </ elegans </ e </ c </ 3 </ study highlights regulate translation rbp family promote memory neurological symptoms neurological phenotypes neurological disorders nervous system memory ability key symptom functionally replace cognitive impairments closest ortholog associative learning 000 rbps
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