Data Sheet 1_SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy.pdf

Data Sheet 1_SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy.pdf

Background<p>Cytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production. It plays a central role in multiple pathways t...

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Bibliographic Details
Main Author: John K. Cini (17677884) (author)
Other Authors: Richard T. Kenney (15289313) (author), Susan Dexter (15289301) (author), Stephen J. McAndrew (17677890) (author), Rukiye-Nazan Eraslan (17677896) (author), Rich Brody (1881121) (author), Darrel J. Rezac (17677887) (author), Rebecca Boohaker (18231014) (author), Suzanne E. Lapi (389414) (author), Pankaj Mohan (17677899) (author)
Published: 2024
Subjects:
Genetic Immunology
interleukin-12
tumor microenvironment
FcRn
SPARC
immunomodulation
fully human albumin binding (FHAB) domain
interferon gamma
immunotherapy
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