Figure 4 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Figure 4 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

<p>TGFβ activates ATM via NOX4-driven DNA damage/MRN complex and oxidation. <b>A–E,</b> HFFF2 were treated with TGFβ1 for 24 hours. <b>A,</b> Western blotting/quantification of HFFF2 treated with TGFβR1 inhibitor. <b>B</b>, Western blotting/quantification of...

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Bibliografiske detaljer
Hovedforfatter: Massimiliano Mellone (14959419) (author)
Andre forfattere: Klaudia Piotrowska (14959422) (author), Giulia Venturi (14959425) (author), Lija James (14959428) (author), Aleksandra Bzura (14959431) (author), Maria A. Lopez (14959434) (author), Sonya James (14959437) (author), Chuan Wang (14959440) (author), Matthew J. Ellis (14959443) (author), Christopher J. Hanley (14941671) (author), Josephine F. Buckingham (14959446) (author), Kerry L. Cox (14959449) (author), Gareth Hughes (14959452) (author), Viia Valge-Archer (14959455) (author), Emma V. King (14959458) (author), Stephen A. Beers (14959461) (author), Vincent Jaquet (14959464) (author), George D.D. Jones (14959467) (author), Natalia Savelyeva (14959470) (author), Emre Sayan (14959473) (author), Jason L. Parsons (14959476) (author), Stephen Durant (14959479) (author), Gareth J. Thomas (14941701) (author)
Udgivet: 2025
Fag:
Cancer
Tumor Biology
Molecular and Cellular Biology
Immuno-oncology
Methods and Technology
DNA Damage and Repair
Immunotherapy
Combination immunotherapy
Preclinical Models
Animal models of cancer
Tumor Microenvironment
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