Clozapine modulated apoptosis and autophagy in MCF-7 cells.

<p>MCF-7 cells were seeded into 6-well plates at a density of 10<sup>5</sup> cells/well and treated with an indicated concentration of clozapine for 72 h. Cells were harvested and stained with (A) 0.25 μg/mL of acridine orange and (C) fluorescein-conjugated Annexin V antibody and p...

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Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Prif Awdur:	Ya-Chun Fan (21567690) (author)
Awduron Eraill:	Shih-Chao Lin (3753646) (author), Po-Jung Lai (630383) (author), Pei-Chun Lai (10132949) (author), Germain Maurus (21567693) (author), Shiow-Yi Chen (160980) (author)
Cyhoeddwyd:	2025
Pynciau:	Biochemistry Cell Biology Molecular Biology Physiology Pharmacology Biotechnology Immunology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified western blotting analyses g1 phase arrest assess cell proliferation reduces cell viability induced cell death breast cancer cells term antipsychotic treatment ros ), apoptosis clozapine induces apoptosis reduces ros induced apoptosis antipsychotic drugs induced cytotoxicity similar ros ros plays ros generation induces autophagy used clonogenic upregulating p21 tumor effects therapeutic agent study investigates study demonstrates results show psychotic disorders psychiatric medication previous studies mtt assays flow cytometry findings suggest combining clozapine clozapine suppresses central role 231 cells
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Clozapine modulated apoptosis and autophagy in MCF-7 cells.

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